Diffuse midline glioma

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  • 20-year-old patient presetned with headaches, blurred vision, nausea and vomitting.
  • MRI showed a diffuse T2-hyperintense lesion centred in a mildly expanded cerebellar peduncle.
  • Lower ADC values, potentially representing areas of higher celluarity, corresponded to a region of mildly increased rCBV (1.4 relative to the contralateral side).

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  • 20-year-old patient presented with acute onset headache.
  • MRI showed a acute obstructive hydrocephalus secondary to a solid-cystic lesion centred on the left thalamus.
  • Low ADC values within the solid and enhancing component of the tumor indicated hyperceullarity.
  • Biopsy revealed a H3 K27M-mutant diffuse midline glioma.

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  • A 55-year-old patient presented with headache, nausea and vomitting.
  • MRI showed an enhancing lesion in the right side of the pons with slightly reduced ADC values.
  • Given an extensive travel history the imaging differential included both neoplasta and infection/inflammation.
  • Biopsy revealed an H3 27M-mutant diffuse midline glioma.