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Case of the Month: October 2025

Case history

  • 50-year-old patient with a history of cranial irradiation for a CNS tumour 20 years ago presented with headache, confusion and left-sided weakness.

smart_syndrome_1

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SMART Syndrome

  • MRI showed subtle increase in T2-weighted hyperintensity in the right frontal cortex and gyriform enhancement.
  • CSF analysis showed no evidence of disease recurrence.
  • Imaging 1 year later showed partial resolution of the gyral enhancement, consistent with Stroke-like Migraine Attacks after Radiation Therapy (SMART) syndrome.

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