Case of the Month: December 2025
Case history
- 40-year-old patient with longstanding epilepsy had their anti-epileptic medication changed following an increase in seizure frequency.
Click to reveal diagnosis
Cytotoxic Lesion of the Corpus Callosum (CLOCC)
- CT showed low density in the splenium of the corpus callosum.
- On MRI, there was T2-hyperintensity and diffusion restriction in the splenium of the corpus callosum.
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A cytotoxic lesion of the corpus callosum (CLOCC) is a reversible clinicoradiological entity associated with a wide range of aetiologies including anti-epileptic drug changes, metabolic disturbances, and infection.